TARGETING REGULATED CELL DEATH (RCD) WITH SMALL-MOLECULE COMPOUNDS IN TRIPLE-NEGATIVE BREAST CANCER: A REVISITED PERSPECTIVE FROM MOLECULAR MECHANISMS TO TARGETED THERAPIES

Abstract Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies currently available.Regulated cell death (RCD), also known as programmed cell death (PCD), glassware has been widely reported to have numerous links to the progression and therapy of many types o

Wear on a metal can be naturally found in components that operate in a friction environment, such as in a transmission system.However, it can be a substantial problem when the wear rate is not within the permitted limit.Surface hardening is a popular way to improve surface wear resistance for metals with various parameters that can be controlled du

The monotypic fern genus Dryopolystichum Copel.combines a unique assortment of characters that obscures its relationship to other ferns.Its thin-walled sporangium with a vertical and interrupted annulus, round sorus with peltate indusium, and petiole with several vascular bundles place it in suborder Polypodiineae, but more precise placement has el

Purpose: The aim of this article is to discuss to what extent and in what ways the Sami people are included in national imaginary in textbooks.The article sheds critical light on important aspects of democracy, inclusion and multi-culturalism in education through the example of indigenous peoples in Norway.The article also explores what opportuniti

Biological limit reference points (LRPs) for fisheries catch represent upper bounds that avoid undesirable population states.LRPs can support consistent management science toy evaluation among species and regions, and can advance ecosystem-based fisheries management.For transboundary species, LRPs prorated by local abundance can inform local manage